A Research Article on Formulation, Development and Evaluation of Prosopis Cineraria Based Topical Gel

Abstract

The present study focuses on the formulation and evaluation of a topical herbal gel incorporating Prosopis cineraria extract, known for its traditional medicinal properties including anti-inflammatory, antimicrobial, and wound-healing effects. The extract was obtained using a hydroalcoholic solvent system through Soxhlet extraction. The gel was formulated using hydroxyethyl cellulose (HEC) as a gelling agent and evaluated for various physicochemical parameters such as pH, viscosity, spreadability, extrudability, and stability. Furthermore, the antimicrobial activity of the gel was assessed against common skin pathogens including Staphylococcus aureus and Escherichia coli using the agar well diffusion method. The results indicated that the formulated gel was stable, non-irritant, and exhibited significant antimicrobial properties, suggesting its potential as an effective herbal topical formulation for treating skin infections and promoting dermal health.